Hypoallergenic acid-sensitive modification preserves major mugwort allergen fold and delivers full repertoire of MHC class II-binding peptides during endolysosomal degradation
نویسندگان
چکیده
منابع مشابه
Functional consequences of the binding of MHC class II-derived peptides to MHC class II.
Three MHC class II-derived synthetic peptides (I-A beta (g7)1-16, I-A beta (g7)52-77 and I-A alpha (g7)63-82YC) were analyzed for their ability to bind to syngeneic and allogeneic MHC class II molecules using a whole cell, competitive peptide binding assay. These studies demonstrated that the A beta (g7)1-16 peptide was able to specifically bind to syngeneic as well as to four allogeneic MHC cl...
متن کاملMotifs and supermotifs for MHC class II binding peptides
I n the last few years, our understanding of the mechanisms 9 involved in the interaction between major histocompatibility complex (MHC) class II molecules and antigenic peptides has greatly increased. The determination of the x-ray structure of a human class II molecule (1, 2), the selection of large, class II-bound, peptide repertoires using M13 peptide display libraries (3, 4), and the chara...
متن کاملPredicting the binding affinity of MHC class II peptides.
MHC (Major Histocompatibility Complex) proteins are categorized under the heterodimeric integral membrane proteins. The MHC molecules are divided into 2 subclasses, class I and class II. Two classes differ from each other in size of their binding pockets. Predicting the affinity of these peptides is important for vaccine design. It is also vital for understanding the roles of immune system in v...
متن کاملBuilding a meta-predictor for MHC class II-binding peptides.
Prediction of class II major histocompatibility complex (MHC)-peptide binding is a challenging task due to variable length of binding peptides. Different computational methods have been developed; however, each has its own strength and weakness. In order to provide reliable prediction, it is important to design a system that enables the integration of outcomes from various predictors. In this c...
متن کاملChemical modification of Art v 1, a major mugwort pollen allergen, by cis-aconitylation and citraconylation
Art v 1 is the major allergen of mugwort (Artemisia vulgaris) pollen, a significant cause of hay fever all over Europe. Specific immunotherapy is the only treatment modality for allergic disease. Application of modified allergens makes the treatment safer and more efficient. In this work, two out of three (citraconic anhydride, cis-aconitic anhydride, 2,3-dimethylmaleic anhydride) tested anhydr...
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2016
ISSN: 2046-2069
DOI: 10.1039/c6ra17261j